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Research

Contact Dr. Lorenzo Del Sorbo
TGH Research Director

Contact Dr. Sangeeta Mehta
MSH Research Director

Critical Care Research

Our research focuses on several themes including Acute Respiratory Distress Syndrome, Neuro-Critical Care, and long term outcomes following critical illness, among many others. We are actively investigating how to best use novel diagnostic and therapeutic technologies for mechanical ventilation and extra-corporeal life support. Our scientists lead multi-centre studies and collaborate with research consortia nationally and internationally, including the Canadian Critical Care Trials Group. Read more at the tabs below.

Major Research Areas

Current Major Research Areas:

  • Acute Kidney Injury and Renal Replacement Therapy
  • Acute Respiratory Distress Syndrome
  • COVID-19 Treatment and Supportive Care
  • Critical Illness in Pregnancy
  • Diaphragm Function in Critical Illness
  • Ethics and Communication
  • Extracorporeal Life Support
  • ICU Management of Multiorgan Transplant Patients
  • Influenza and Pandemic Planning
  • Long-term Patient and Family Outcomes after Critical Illness
  • Mechanical Ventilation
  • Neurosciences and Neurocritical Care
  • Oncological Critical Care
  • Point-of-Care Ultrasound in Critically Ill Patients
  • Post-ICU Psychological and Neurocognitive Outcomes
  • Pulmonary Hypertension
  • Quality Improvement
  • Sedation, Analgesia, and Delirium in the ICU

 

 

Ongoing Studies

Current Ongoing Studies:

  • A-FREE ECMO – Anticoagulation Free VV-ECMO for acute respiratory failure (Site PI: E. Fan)
  • AiCLOSE – Airway Closure during Extracorporeal membrane oxygenation (PI: L. Del Sorbo)
  • ALIVE – Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure (Site PI: E. Goligher)
  • BALANCE – Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (Site PIs: B. Coburn, L. DelSorbo)
  • CANCOV – The Canadian COVID-19 Prospective Cohort Study (Site PI: M. Herridge)
  • CAVIARDS – CAreful Ventilation In ARDS (Site PI: E. Goligher)
  • EB05 – A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients with COVID-19 (Site PI: L. Del Sorbo)
  • HONOUR – High-Flow Nasal Oxygen with or without Helmet Non-invasive Ventilation for Oxygenation Support in Acute Respiratory Failure (Site PI: L. Del Sorbo)
  • iCORE – multicentre ICU quality and research database (Site PI: E. Fan)
  • INDEX – International Research Database for Extracorporeal Support (Site PI: E. Fan)
  • INTEGRATION – Inspiratory Work of Breathing Before and After Extubation (Site PI: E. Goligher)
  • International prospective multicenter observational study of the safety and performance of bellavista ventilator and the iFLow sensor during routine use in the neonatal, pediatric, and adult intensive care unit (Site PI: L. Del Sorbo)
  • iNOCAPA – inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA): A pilot randomized controlled trial and translational biology study (Site PI: J. Granton)
  • LANDMARK – Lung and Diaphragm-Protective Ventilation By Means of Assessing Respiratory Work (Site PI: E. Goligher)
  • MYOTRAUMA – observational study of diaphragm function with ultrasound (Site PI: E. Goligher)
  • PROMIZING – Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (Site PI: E. Goligher)
  • REMAP-CAP- Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia (Site PIs: E. Wilcox, L. Del Sorbo)
  • SAVE-ICU – Sedating With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival (Site PI: E. Goligher)
  • SOLVE ARDS – Strategies for Optimal Lung Ventilation in ECMO for ARDS  (Site PI: L. Del Sorbo)
  • The RECOVER Program – REhabilitation and ReCOVERy in Surviviors of Critical Illness (Site PI: M.  Herridge

 

Upcoming Studies

Current Upcoming Studies:

Investigator-Initiated/CCCTG

  • ECMO-Free
  • ECMO-Rehab
  • MAGNAM
  • ULTIMATE
  • WEAN-VAECLS
  • WEAN-VVECLS

Industry Sponsored

  • SEAL Trial

Select Publications

SELECTED PUBLICATIONS

  1. Alali AS, McCredie V, Mainprize TG, Gomez D, Nathens AB. Structure, process and culture of intensive care units treating patients with severe traumatic brain injury: survey of centers participating in the American College of Surgeons Trauma Quality Improvement Program. J Neurotrauma 2017, in press.
  2. Burry L, Scales D, Williamson D, Foster J, Mehta S, Guenette M, Fan E, Detsky M, Azad A, Bernard F, Rose L. Feasibility of melantonin for prevention of delirium in critically ill patients: a protocol for a multicentre, randomised, placebo-controlled study. BMJ Open 2017;30:e015420.
  3. Mehta S, Burns KE, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS. Gender parity in critical care medicine. Am J Respir Crit Care Med 2017, in press.
  4. Herridge MS, Tansey CM, Matte A, Tomlinson G, Diaz-Granados N, Cooper A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011 Apr 7;364(14):1293-304.
  5. Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med. 2013 Feb 1;187(3):238-46.
  6. Herridge MS and Cameron JI. Disability after Critical Illness. N Engl J Med 2013; 369:1367- 136.
  7. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand LE, Austin, P, Zhou Q, Matte A, Walter F, Lamontagne F, Granton JT, Arabi Y, Arroliga A, Stewart TE, Slutsky AS, Meade MO, for the OSCILLATE Trial Investigators and the Canadian Critical Care Trials Group. Early high- frequency oscillation for patients with acute respiratory distress syndrome: A randomized controlled trial. New Engl J Med 2013; 368:795-805
  8. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS, for the ARDS Definition Task Force. Acute respiratory distress syndrome: The Berlin definition. JAMA 2012;307:2526-2533.
  9. Fan E, Laupacis A, Pronovost PJ, Guyatt GH, Needham DM. Users’ guide to the medical literature: how to use an article on quality improvement. JAMA 2010; 304:2287-2295.
  10. Pipeling MR, Fan E. Therapies for refractory hypoxemia in acute respiratory distress syndrome. JAMA 2010; 304:2521-2527.
  11. Downar J. Kritek PA. Family presence during resuscitation. New Engl J Med. 2013 Mar;368(11):1060-2.
  12. Singh JM, MacDonald RD, Bronskill SE, Schull MJ. Incidence and predictors of critical events during urgent air-medical transport. Can Med Assoc J. 2009 Oct 27;181(9):579-84.
  13. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302:1872-9
  14. Peñuelas O, Frutos-Vivar F, Fernandez C, Anzueto A, Epstein SK, Apezteguía C, González M, Nin N, Raymondos K, Tomicic V, Desmery P, Arabi Y, Jibaja M, Matamis D, Pelosi P, Ferguson ND, Esteban A, for the Ventila Group. Characteristics and Outcomes of Ventilated Patients According to Time to Liberation from Mechanical Ventilation. Am J Respir Crit Care Med 2011; 184:430-437.
  15. Sud S, Sud M, Friedrich JO, Meade MO, Ferguson ND, Wunsch H, Adhikari NK. High frequency oscillation in acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. BMJ 2010 340:c2327
  16. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gardlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD, for the PROWESS-SHOCK Study Group. Drotrecogin Alfa (Activated) in Adults with Septic Shock. New Engl J Med 366:2055-64.
  17. The NICE-SUGAR Study Investigators. Hypoglycemia and Risk of Death in Critically Ill Patients. New Engl J Med. 2012; 367:1108-1118.
  18. Mehta S, Burry L, Cook DJ, Fergusson D, Steinberg M, Granton JT, Herridge MS, Ferguson ND, Devlin J, Tanois M, Dodek P, Fowler RA, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade MO for the SLEAP Investigators and Canadian Critical Care Trials Group. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for with a Sedation Protocol: A Randomized Trial. JAMA. Nov 21;308(19):1985-92.
  19. Ferguson ND, Scales DC, Pinto R, Wilcox ME, Cook DJ, Guyatt GH, Schünemann HJ, Marshall JC, Herridge MS, Meade MO; for the Canadian Critical Care Trials Group. Integrating Mortality and Morbidity Outcomes: Using Quality-Adjusted Life Years in Critical Care Trials. Am J Respir Crit Care Med. 2012 Nov 30.
  20. Bienvenu OJ, Colantuoni, Mendez-Tellez PA, Dinglas VD, Shanholtz C, Husain N, Dennison CR, Herridge MS, Pronovost PJ, Needham DM. Depressive Symptoms and Impaired Physical Function after Acute Lung Injury: A 2-Year Longitudinal Study. Am J Respir Crit Care Med 2012; 185: 517-524.
  21. Keenan SP, Sinuff T, Burns K, Muscedere J, Kutsogiannis J, Mehta S, Dodek P, Cook DJ, Ayas N, Adhikari N, Hand L, Scales D, Pagnotta R, Lazosky L, Rocker G, Dial S, Laupland K, Sanders K, for The Canadian Critical Care Trials Group (CCCTG) and Canadian Critical Care Society (CCCS) Noninvasive Ventilation Guidelines Group. Clinical practice guidelines for noninvasive positive pressure ventilation (NPPV) and noninvasive continuous positive airway pressure (nCPAP) in the acute care setting. Can Med Assoc J 2011; 22;183(3):E195- 214. Epub February 14, 2011.
  22. Dalteparin versus Unfractionated Heparin in Critically Ill Patients. The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. N Engl J Med 2011; 364:1305-1315.
  23. Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand LE, Austin, P, Zhou Q, Matte A, Walter F, Lamontagne F, Granton JT, Arabi Y, Arroliga A, Stewart TE, Slutsky AS, Meade MO, for the OSCILLATE Trial Investigators and the Canadian Critical Care Trials Group. Early high- frequency oscillation for patients with acute respiratory distress syndrome: A randomized controlled trial. NEJM 2013; 368:795-805
  24. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, Meade M, for the SLEAP Investigators and the Canadian Critical Care Trials Group. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: A randomized controlled trial. JAMA 2012; 308(19):1985-1992
  25. Lapinsky SE. Critical illness as a result of influenza A/H1N1 infection in pregnancy. BMJ. 2010;340:c1235.
  26. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302:1872-9
  27. Domínguez-Cherit G, Lapinsky SE, Macias AE, Pinto R, Espinosa-Perez L, de la Torre A, Poblano-Morales M, Baltazar-Torres JA, Bautista E, Martinez A, Martinez MA, Rivero E, Valdez R, Ruiz-Palacios G, Hernández M, Stewart TE, Fowler RA. Critically Ill patients with 2009 influenza A(H1N1) in Mexico. JAMA. 2009;302:1880-7

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