• Academic Rank
    Assistant Professor
  • Position Title
    Clinician-Investigator
  • Area of Academic Focus

    Extra corporeal life support: Translational research on mechanisms of organ injury and therapeutic approaches in cells and animal models of critical illness

  • Publications

    Link to Pubmed

  • Email
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  • Phone

Bio

Lorenzo Del Sorbo is an intensive care attending at Toronto General Hospital, since appointment in 2016. He graduated in Medicine at the University of Torino, Italy. He trained in Internal Medicine at the University of Torino, and in adult Critical Care Medicine at the University of Toronto. He was appointed and worked as an Assistant Professor of Intensive Care Medicine at the University of Torino, Italy.

Lorenzo’s main academic interests focus on the application of innovative strategies to prevent the injury induced by invasive mechanical ventilation. These include investigations in extra-corporeal life support strategies in patients with ARDS and COPD exacerbation and in non-invasive ventilation. His work also extends into the translational research defining the mechanisms of organ injury and developing novel therapeutic approaches in cell and animal models of critical illness.

Affiliations

  • Department of Respirology, Critical Care Medicine, Department of Medicine, University Health Network

Previous Appointments

  • Assistant Professor of Intensive Care Medicine at the University of Torino, Italy (2007-2012)

Honours and Awards

  • 2004 – Postgraduate Fellowship Award, Department of Medicine, University of Toronto, Ontario, Canada
    Project title: “Molecular mechanisms of interaction between cytokines and bacteria in animal models of ventilation associated pneumonia”

Significant Publications

  1. Del Sorbo L, Costamagna A, Muraca G, Rotondo G, Civiletti F, Vizio B, Bosco O, Martin Conte E, Delsedime L, Lupia E, Fanelli V, and Ranieri VM. Intra-tracheal administration of small interfering RNA targeting Fas reduces lung ischemia-reperfusion injury. Crit Care Med. 2016
  2. Del Sorbo L, Pisani L, Filippini C, Fanelli V, Fasano L, Terragni P, Dell’Amore A, Urbino R, Mascia L, Evangelista A, Antro C, D’Amato R, Sucre MJ, Simonetti U, Persico P, Nava S and Ranieri VM. Extracorporeal carbon dioxide removal in hypercapnic patients at risk of non-invasive ventilation failure: a matched cohort study with historical control. Crit Care Med. 2015
  3. Del Sorbo L, Cypel M and Fan E. Extracorporeal life support for adults with severe acute respiratory failure. Lancet Respir Med. 2014
  4. Del Sorbo L, Ranieri VM. We do not need mechanical ventilation any more. Crit Care Med. 2010
  5. Terragni PP, Del Sorbo L, Mascia L, Urbino R, Martin EL, Birocco A, Faggiano C, Quintel M, Gattinoni L, Ranieri VM. Tidal Volume Lower than 6 ml/kg Enhances Lung Protection: Role of Extracorporeal Carbon Dioxide Removal. Anesthesiology. 2009

Ongoing Studies

  • AiCLOSE

    Airway Closure during Extracorporeal membrane oxygenation

  • EB05

    A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients with COVID-19

  • HONOUR

    High-Flow Nasal Oxygen with or without Helmet Non-invasive Ventilation for Oxygenation Support in Acute Respiratory Failure

  • SOLVE ARDS

    Strategies for Optimal Lung Ventilation in ECMO for ARDS

  • BALANCE

    Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness

  • REMAP-CAP

    Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia