• Area of Academic Focus
    • Mechanisms and outcomes of patient-ventilator interaction
    • Respiratory muscle injury from mechanical ventilation and its impact on patient outcomes
  • Publications

    Link to PubMed

  • Email
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Bio

Ewan Goligher MD, PhD is an Associate Professor of Medicine and Physiology at the University of Toronto and Senior Scientist at the Toronto General Hospital Research Institute. His research program focuses on characterizing the mechanisms and impact of injury to the lung and diaphragm during mechanical ventilation and on the use of innovative clinical trial designs to test precision medicine strategies for hypoxemic respiratory failure. He co-chairs the PRACTICAL international adaptive platform trial testing novel interventions for acute hypoxemic respiratory failure, and he sits on the executive committee for the PANTHER adaptive platform trial.

Affiliations

  • Associate Professor of Medicine and Physiology, University of Toronto
  • Senior Scientist, Toronto General Hospital Research Institute (TGHRI)
  • Attending Physician, Medical-Surgical ICU, Toronto General Hospital
  • Co-chair, PRACTICAL platform adaptive trial

Honours and Awards

  • 2022: Annual site teaching award, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • 2019: Global Rising Star Fellowship, Australia/New Zealand Intensive Care Society
  • 2019: IDCCM Scholar, University of Toronto

Significant Publications

  1. Dianti J, Lovblom LE, Iftikhar MA, Sahetya S, Telias I, Urner M, Del Sorbo L, Amato MBP, Slutsky AS, Brochard L, Ferguson ND, Fan E, Goligher EC. Association of respiratory drive and effort with mortality and time to discharge in patients on mechanical ventilation in Canada: a longitudinal, prospective, registry-based cohort study. Lancet Respir Med. 2025 Sep 19:S2213-2600(25)00297-8. doi: 10.1016/S2213-2600(25)00297-8.
  2. Morris IS, Bassi T, Bellissimo CA, Bootjeamjai P, Roman-Sarita G, de Perrot M, Donahoe L, McRae K, Dianti J, Del Sorbo L, Keshavjee S, Cypel M, Reynolds SC, Dres M, Thakkar V, Mehta N, Brochard L, Ferguson ND, Goligher EC. Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS). Am J Respir Crit Care Med. 2025 Mar 5.
  3. Goligher EC, Heath A, Harhay MO. Bayesian statistics for clinical research. The Lancet. 2024 Sep 14;404(10457):1067-1076.
  4. REMAP-CAP Investigators., ACTIV-4a Investigators., ATTACC Investigators., Goligher EC, Bradbury CA, McVerry BJ, et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789.
  5. Goligher EC, Brochard LJ, Reid WD, Fan E, Saarela O, Slutsky AS, Kavanagh BP, Rubenfeld GD, Ferguson ND. Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. Lancet Respir Med. 2019 Jan;7(1):90-98.

Ongoing Studies

  • SAVE-ICU

    Sedating With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival

  • ALIVE

    Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure

  • CAVIARDS

    Careful Ventilation In ARDS

  • INTEGRATION

    Inspiratory Work of Breathing Before and After Extubation

  • LANDMARK

    Lung and Diaphragm-Protective Ventilation By Means of Assessing Respiratory Work

  • MYOTRAUMA

    observational study of diaphragm function with ultrasound

  • PROMIZING

    Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation