Dr. Aleksandra Leligdowicz


Dr. Aleksandra Leligdowicz

Attending Physician, Toronto Western Hospital

Academic Rank
Clinical Associate

Position Title
Postdoctoral Research Fellow

Medical/Professional Qualifications

Toronto General Research Institute (TGRI)
University of California, San Francisco (UCSF) Cardiovascular Research Institute (CVRI)

Dr. Leligdowicz completed her medical degree at McGill University and a PhD at Oxford University as a Rhodes Scholar in HIV immunology in West Africa. She completed an internal medicine residency at the University of British Columbia and a critical care medicine fellowship at the University of Toronto. She pursued her interest in immunology and severe infection as a postdoctoral research fellow at University of Toronto and University of California, San Francisco. Her research focuses on characterizing the relationship between immune activation and endothelial injury, with a goal of elucidating mechanisms of tissue injury resulting from severe infection in critically ill patients. Understanding these pathways may lead to novel therapeutic targets for life-threatening infections. Identifying prognostic biomarkers may lead to the development of point-of-care diagnostic tests that risk-stratify critical illness outcome, in both developed and resource-limited settings.

Area of Academic Focus
Translational medicine research, relationship between the immune system and endothelial injury in critical illness and their role in the pathobiology of life-threatening infection

Honours and Awards
CIHR Banting Postdoctoral Fellowship (2015-18)
Clinician Scientist Training Program, Department of Medicine, U of T (2015-18)
G.B. John Mancini Resident Research Achievement Prize, UBC (2013)
Nuffield Department of Medicine Student of the Year, Oxford University (2009)
Rhodes Scholarship, Canadian recipient (2004-08)

Link to Pubmed

Most Significant Publications

  1. Leligdowicz A, Fischer WA, 2nd, Uyeki TM, Fletcher TE, Adhikari NK, Portella G, Lamontagne F, Clement C, Jacob ST, Rubinson L et al: Ebola virus disease and critical illness. Crit Care 2016, 20(1):217.
  2. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S, International Forum for Acute Care T: Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. American journal of respiratory and critical care medicine 2016, 194(7):911-912.
  3. Leligdowicz A, Dodek PM, Norena M, Wong H, Kumar A, Kumar A: Association between source of infection and hospital mortality in patients who have septic shock. American journal of respiratory and critical care medicine 2014, 189(10):1204-1213.
  4. Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL: Is nosocomial infection really the major cause of death in sepsis? Crit Care 2014, 18(5):540.
  5. Leligdowicz A, Onyango C, Yindom LM, Peng Y, Cotten M, Jaye A, McMichael A, Whittle H, Dong T, Rowland-Jones S: Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. European journal of immunology 2010, 40(7):1963-1972.




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