Dr. Lorenzo Del Sorbo
Research Director, Toronto General Hospital
Department of Respirology/ Critical Care Medicine, Department of Medicine, University Health Network, Toronto, Ontario, Canada
Lorenzo Del Sorbo is an intensive Care attending at Toronto General Hospital, since appointment in 2016. He graduated in Medicine at the University of Torino, Italy. He trained in Internal Medicine at the University of Torino, and in adult Critical Care Medicine at the University of Toronto. He was appointed and worked as an Assistant Professor of Intensive Care Medicine at the University of Torino, Italy. Lorenzo’s main academic interests focus on the application of innovative strategies to prevent the injury induced by invasive mechanical ventilation. These include investigations on extra-corporeal life support strategies in patients with ARDS and COPD exacerbation, on non-invasive ventilation. His work also extends into the translational research defining the mechanisms of organ injury and developing novel therapeutic approaches in cell and animal models of critical illness.
Assistant Professor of Intensive Care Medicine at the University of Torino, Italy (2007-2012)
Area of academic focus
Extra corporeal Life Support
Translational research on mechanisms of organ injury and therapeutic approaches in cells and animal models of critical illness
Honours and Awards
2004 Postgraduate Fellowship Award, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Project title: “Molecular mechanisms of interaction between cytokines and bacteria in animal models of ventilation associated pneumonia”.
Link to Pubmed
Most Significant Publications:
- Del Sorbo L, Costamagna A, Muraca G, Rotondo G, Civiletti F, Vizio B, Bosco O, Martin Conte E, Delsedime L, Lupia E, Fanelli V, and Ranieri VM. Intra-tracheal administration of small interfering RNA targeting Fas reduces lung ischemia-reperfusion injury. Crit Care Med. 2016
- Del Sorbo L, Pisani L, Filippini C, Fanelli V, Fasano L, Terragni P, Dell’Amore A, Urbino R, Mascia L, Evangelista A, Antro C, D’Amato R, Sucre MJ, Simonetti U, Persico P, Nava S and Ranieri VM. Extracorporeal carbon dioxide removal in hypercapnic patients at risk of non-invasive ventilation failure: a matched cohort study with historical control. Crit Care Med. 2015
- Del Sorbo L, Cypel M and Fan E. Extracorporeal life support for adults with severe acute respiratory failure. Lancet Respir Med. 2014
- Del Sorbo L, Ranieri VM. We do not need mechanical ventilation any more. Crit Care Med. 2010
- Terragni PP, Del Sorbo L, Mascia L, Urbino R, Martin EL, Birocco A, Faggiano C, Quintel M, Gattinoni L, Ranieri VM. Tidal Volume Lower than 6 ml/kg Enhances Lung Protection: Role of Extracorporeal Carbon Dioxide Removal. Anesthesiology. 2009